MaghrebDataLibMedV2, Main, Exploration, bibRecord, 000370

Thirty Years of Experience at the First Tunisian Kidney Transplant Center.

Identifieur interne : 000370 ( Main/Exploration ); précédent : 000369; suivant : 000371

Thirty Years of Experience at the First Tunisian Kidney Transplant Center.

Auteurs : Ezzedine Abderrahim [Tunisie] ; Asma Zammouri ; Mohamed Mongi Bacha ; Mondher Ounissi ; Tahar Gargah ; Hafedh Hedri ; Riadh Ben Slama ; Rafika Bardi ; Mohamed Chebil ; Taieb Ben Abdallah

Source :

Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation [ 2146-8427 ] ; 2017.

RBID : pubmed:28260441

Descripteurs français

KwdFr :
- Adolescent (MeSH), Adulte (MeSH), Adulte d'âge moyen (MeSH), Analyse de survie (MeSH), Connaissances, attitudes et pratiques en santé (MeSH), Dialyse rénale (MeSH), Donneur vivant (ressources et distribution), Donneurs de tissus (ressources et distribution), Défaillance rénale chronique (chirurgie), Défaillance rénale chronique (diagnostic), Défaillance rénale chronique (mortalité), Enfant (MeSH), Facteurs de risque (MeSH), Facteurs socioéconomiques (MeSH), Facteurs temps (MeSH), Femelle (MeSH), Humains (MeSH), Immunosuppresseurs (usage thérapeutique), Jeune adulte (MeSH), Loi du khi-deux (MeSH), Mort cérébrale (MeSH), Mâle (MeSH), Rejet du greffon (immunologie), Rejet du greffon (prévention et contrôle), Résultat thérapeutique (MeSH), Sujet âgé (MeSH), Survie du greffon (MeSH), Transplantation rénale (effets indésirables), Transplantation rénale (mortalité), Tunisie (MeSH), Évaluation de programme (MeSH).
MESH :
- chirurgie : Défaillance rénale chronique.
- diagnostic : Défaillance rénale chronique.
- effets indésirables : Transplantation rénale.
- immunologie : Rejet du greffon.
- mortalité : Défaillance rénale chronique, Transplantation rénale.
- prévention et contrôle : Rejet du greffon.
- ressources et distribution : Donneur vivant, Donneurs de tissus.
- usage thérapeutique : Immunosuppresseurs.
- Adolescent, Adulte, Adulte d'âge moyen, Analyse de survie, Connaissances, attitudes et pratiques en santé, Dialyse rénale, Enfant, Facteurs de risque, Facteurs socioéconomiques, Facteurs temps, Femelle, Humains, Jeune adulte, Loi du khi-deux, Mort cérébrale, Mâle, Résultat thérapeutique, Sujet âgé, Survie du greffon, Tunisie, Évaluation de programme.

English descriptors

KwdEn :
- Adolescent (MeSH), Adult (MeSH), Aged (MeSH), Brain Death (MeSH), Chi-Square Distribution (MeSH), Child (MeSH), Female (MeSH), Graft Rejection (immunology), Graft Rejection (prevention & control), Graft Survival (MeSH), Health Knowledge, Attitudes, Practice (MeSH), Humans (MeSH), Immunosuppressive Agents (therapeutic use), Kidney Failure, Chronic (diagnosis), Kidney Failure, Chronic (mortality), Kidney Failure, Chronic (surgery), Kidney Transplantation (adverse effects), Kidney Transplantation (mortality), Living Donors (supply & distribution), Male (MeSH), Middle Aged (MeSH), Program Evaluation (MeSH), Renal Dialysis (MeSH), Risk Factors (MeSH), Socioeconomic Factors (MeSH), Survival Analysis (MeSH), Time Factors (MeSH), Tissue Donors (supply & distribution), Treatment Outcome (MeSH), Tunisia (MeSH), Young Adult (MeSH).
MESH :
- chemical , therapeutic use : Immunosuppressive Agents.
- adverse effects : Kidney Transplantation.
- diagnosis : Kidney Failure, Chronic.
- immunology : Graft Rejection.
- mortality : Kidney Failure, Chronic, Kidney Transplantation.
- prevention & control : Graft Rejection.
- supply & distribution : Living Donors, Tissue Donors.
- surgery : Kidney Failure, Chronic.
- Adolescent, Adult, Aged, Brain Death, Chi-Square Distribution, Child, Female, Graft Survival, Health Knowledge, Attitudes, Practice, Humans, Male, Middle Aged, Program Evaluation, Renal Dialysis, Risk Factors, Socioeconomic Factors, Survival Analysis, Time Factors, Treatment Outcome, Tunisia, Young Adult.

Abstract

OBJECTIVES

The aim of this study was to report the results of 30 years of experience at the first kidney transplant center in Tunisia.

MATERIALS AND METHODS

All kidney transplants performed at the center between June 1986 and June 2016 were included. The study period was divided into 3 decades. Recipient and donor data and follow-up information were obtained from a local database and patient medical records. Comparative analyses were performed using the t test for continuous variables and the Χ² test for qualitative variables. Patient and graft survival rates were calculated according to the actuarial method, and comparison of survival curves was performed according to the logrank test.

RESULTS

The mean age of recipients was 32.7 ± 11.5 years (range, 6-65 y) with a gender ratio of 2.2. Duration of prekidney transplant dialysis varied from 2 months to 20 years (median, 27.5 mo); 1.7% of patients underwent transplant preemptively. Kidneys were recovered from deceased donors in 21.2% of cases and from living donors in 78.8%. The proportion of deceased donors dropped from 27.4% during the period 2006-2010 to 12.9% during the period 2011-2015 (P < .04). Patient survival rates at 1, 5, 10, 15, and 20 years were 96%, 89.3%, 79.5%, 71.1%, and 65.4%. Graft survival rates were 95%, 86.5%, 76.2%, 66.3%, and 57.2%. The annual graft loss was 2.9%, with a mortality rate of 2.4% and without significant differences between patients receiving deceased-donor and living-donor organs.

CONCLUSIONS

Kidney transplant activity remains suboptimal in our country. The reduction in deceased-donor organs could be related to the political transformations facing our country with their resulting social and economic consequences. Efforts should be made to increase governmental resources and to improve both public awareness of organ donation and the motivation of transplant teams.

DOI: 10.6002/ect.mesot2016.O66
PubMed: 28260441

Affiliations:

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Le document en format XML

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<author><name sortKey="Abderrahim, Ezzedine" sort="Abderrahim, Ezzedine" uniqKey="Abderrahim E" first="Ezzedine" last="Abderrahim">Ezzedine Abderrahim</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Nephrology and Internal Medicine, University Tunis El Manar, Charles Nicolle Hospital, Tunis, Tunisia.</nlm:affiliation>
<country xml:lang="fr">Tunisie</country>
<wicri:regionArea>Department of Nephrology and Internal Medicine, University Tunis El Manar, Charles Nicolle Hospital, Tunis</wicri:regionArea>
<placeName><settlement type="city">Tunis</settlement>
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<author><name sortKey="Abderrahim, Ezzedine" sort="Abderrahim, Ezzedine" uniqKey="Abderrahim E" first="Ezzedine" last="Abderrahim">Ezzedine Abderrahim</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Nephrology and Internal Medicine, University Tunis El Manar, Charles Nicolle Hospital, Tunis, Tunisia.</nlm:affiliation>
<country xml:lang="fr">Tunisie</country>
<wicri:regionArea>Department of Nephrology and Internal Medicine, University Tunis El Manar, Charles Nicolle Hospital, Tunis</wicri:regionArea>
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<author><name sortKey="Bacha, Mohamed Mongi" sort="Bacha, Mohamed Mongi" uniqKey="Bacha M" first="Mohamed Mongi" last="Bacha">Mohamed Mongi Bacha</name>
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<author><name sortKey="Hedri, Hafedh" sort="Hedri, Hafedh" uniqKey="Hedri H" first="Hafedh" last="Hedri">Hafedh Hedri</name>
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<author><name sortKey="Ben Slama, Riadh" sort="Ben Slama, Riadh" uniqKey="Ben Slama R" first="Riadh" last="Ben Slama">Riadh Ben Slama</name>
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<author><name sortKey="Bardi, Rafika" sort="Bardi, Rafika" uniqKey="Bardi R" first="Rafika" last="Bardi">Rafika Bardi</name>
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<author><name sortKey="Chebil, Mohamed" sort="Chebil, Mohamed" uniqKey="Chebil M" first="Mohamed" last="Chebil">Mohamed Chebil</name>
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<series><title level="j">Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation</title>
<idno type="eISSN">2146-8427</idno>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent (MeSH)</term>
<term>Adult (MeSH)</term>
<term>Aged (MeSH)</term>
<term>Brain Death (MeSH)</term>
<term>Chi-Square Distribution (MeSH)</term>
<term>Child (MeSH)</term>
<term>Female (MeSH)</term>
<term>Graft Rejection (immunology)</term>
<term>Graft Rejection (prevention & control)</term>
<term>Graft Survival (MeSH)</term>
<term>Health Knowledge, Attitudes, Practice (MeSH)</term>
<term>Humans (MeSH)</term>
<term>Immunosuppressive Agents (therapeutic use)</term>
<term>Kidney Failure, Chronic (diagnosis)</term>
<term>Kidney Failure, Chronic (mortality)</term>
<term>Kidney Failure, Chronic (surgery)</term>
<term>Kidney Transplantation (adverse effects)</term>
<term>Kidney Transplantation (mortality)</term>
<term>Living Donors (supply & distribution)</term>
<term>Male (MeSH)</term>
<term>Middle Aged (MeSH)</term>
<term>Program Evaluation (MeSH)</term>
<term>Renal Dialysis (MeSH)</term>
<term>Risk Factors (MeSH)</term>
<term>Socioeconomic Factors (MeSH)</term>
<term>Survival Analysis (MeSH)</term>
<term>Time Factors (MeSH)</term>
<term>Tissue Donors (supply & distribution)</term>
<term>Treatment Outcome (MeSH)</term>
<term>Tunisia (MeSH)</term>
<term>Young Adult (MeSH)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent (MeSH)</term>
<term>Adulte (MeSH)</term>
<term>Adulte d'âge moyen (MeSH)</term>
<term>Analyse de survie (MeSH)</term>
<term>Connaissances, attitudes et pratiques en santé (MeSH)</term>
<term>Dialyse rénale (MeSH)</term>
<term>Donneur vivant (ressources et distribution)</term>
<term>Donneurs de tissus (ressources et distribution)</term>
<term>Défaillance rénale chronique (chirurgie)</term>
<term>Défaillance rénale chronique (diagnostic)</term>
<term>Défaillance rénale chronique (mortalité)</term>
<term>Enfant (MeSH)</term>
<term>Facteurs de risque (MeSH)</term>
<term>Facteurs socioéconomiques (MeSH)</term>
<term>Facteurs temps (MeSH)</term>
<term>Femelle (MeSH)</term>
<term>Humains (MeSH)</term>
<term>Immunosuppresseurs (usage thérapeutique)</term>
<term>Jeune adulte (MeSH)</term>
<term>Loi du khi-deux (MeSH)</term>
<term>Mort cérébrale (MeSH)</term>
<term>Mâle (MeSH)</term>
<term>Rejet du greffon (immunologie)</term>
<term>Rejet du greffon (prévention et contrôle)</term>
<term>Résultat thérapeutique (MeSH)</term>
<term>Sujet âgé (MeSH)</term>
<term>Survie du greffon (MeSH)</term>
<term>Transplantation rénale (effets indésirables)</term>
<term>Transplantation rénale (mortalité)</term>
<term>Tunisie (MeSH)</term>
<term>Évaluation de programme (MeSH)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Immunosuppressive Agents</term>
</keywords>
<keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Kidney Transplantation</term>
</keywords>
<keywords scheme="MESH" qualifier="chirurgie" xml:lang="fr"><term>Défaillance rénale chronique</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Kidney Failure, Chronic</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Défaillance rénale chronique</term>
</keywords>
<keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Transplantation rénale</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Rejet du greffon</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Graft Rejection</term>
</keywords>
<keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Kidney Failure, Chronic</term>
<term>Kidney Transplantation</term>
</keywords>
<keywords scheme="MESH" qualifier="mortalité" xml:lang="fr"><term>Défaillance rénale chronique</term>
<term>Transplantation rénale</term>
</keywords>
<keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Graft Rejection</term>
</keywords>
<keywords scheme="MESH" qualifier="prévention et contrôle" xml:lang="fr"><term>Rejet du greffon</term>
</keywords>
<keywords scheme="MESH" qualifier="ressources et distribution" xml:lang="fr"><term>Donneur vivant</term>
<term>Donneurs de tissus</term>
</keywords>
<keywords scheme="MESH" qualifier="supply & distribution" xml:lang="en"><term>Living Donors</term>
<term>Tissue Donors</term>
</keywords>
<keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Kidney Failure, Chronic</term>
</keywords>
<keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Immunosuppresseurs</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adolescent</term>
<term>Adult</term>
<term>Aged</term>
<term>Brain Death</term>
<term>Chi-Square Distribution</term>
<term>Child</term>
<term>Female</term>
<term>Graft Survival</term>
<term>Health Knowledge, Attitudes, Practice</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Program Evaluation</term>
<term>Renal Dialysis</term>
<term>Risk Factors</term>
<term>Socioeconomic Factors</term>
<term>Survival Analysis</term>
<term>Time Factors</term>
<term>Treatment Outcome</term>
<term>Tunisia</term>
<term>Young Adult</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term>
<term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Analyse de survie</term>
<term>Connaissances, attitudes et pratiques en santé</term>
<term>Dialyse rénale</term>
<term>Enfant</term>
<term>Facteurs de risque</term>
<term>Facteurs socioéconomiques</term>
<term>Facteurs temps</term>
<term>Femelle</term>
<term>Humains</term>
<term>Jeune adulte</term>
<term>Loi du khi-deux</term>
<term>Mort cérébrale</term>
<term>Mâle</term>
<term>Résultat thérapeutique</term>
<term>Sujet âgé</term>
<term>Survie du greffon</term>
<term>Tunisie</term>
<term>Évaluation de programme</term>
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</teiHeader>
<front><div type="abstract" xml:lang="en"><p><b>OBJECTIVES</b>
</p>
<p>The aim of this study was to report the results of 30 years of experience at the first kidney transplant center in Tunisia.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>MATERIALS AND METHODS</b>
</p>
<p>All kidney transplants performed at the center between June 1986 and June 2016 were included. The study period was divided into 3 decades. Recipient and donor data and follow-up information were obtained from a local database and patient medical records. Comparative analyses were performed using the t test for continuous variables and the Χ² test for qualitative variables. Patient and graft survival rates were calculated according to the actuarial method, and comparison of survival curves was performed according to the logrank test.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>RESULTS</b>
</p>
<p>The mean age of recipients was 32.7 ± 11.5 years (range, 6-65 y) with a gender ratio of 2.2. Duration of prekidney transplant dialysis varied from 2 months to 20 years (median, 27.5 mo); 1.7% of patients underwent transplant preemptively. Kidneys were recovered from deceased donors in 21.2% of cases and from living donors in 78.8%. The proportion of deceased donors dropped from 27.4% during the period 2006-2010 to 12.9% during the period 2011-2015 (P < .04). Patient survival rates at 1, 5, 10, 15, and 20 years were 96%, 89.3%, 79.5%, 71.1%, and 65.4%. Graft survival rates were 95%, 86.5%, 76.2%, 66.3%, and 57.2%. The annual graft loss was 2.9%, with a mortality rate of 2.4% and without significant differences between patients receiving deceased-donor and living-donor organs.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>CONCLUSIONS</b>
</p>
<p>Kidney transplant activity remains suboptimal in our country. The reduction in deceased-donor organs could be related to the political transformations facing our country with their resulting social and economic consequences. Efforts should be made to increase governmental resources and to improve both public awareness of organ donation and the motivation of transplant teams.</p>
</div>
</front>
</TEI>
<affiliations><list><country><li>Tunisie</li>
</country>
<region><li>Gouvernorat de Tunis</li>
</region>
<settlement><li>Tunis</li>
</settlement>
</list>
<tree><noCountry><name sortKey="Bacha, Mohamed Mongi" sort="Bacha, Mohamed Mongi" uniqKey="Bacha M" first="Mohamed Mongi" last="Bacha">Mohamed Mongi Bacha</name>
<name sortKey="Bardi, Rafika" sort="Bardi, Rafika" uniqKey="Bardi R" first="Rafika" last="Bardi">Rafika Bardi</name>
<name sortKey="Ben Abdallah, Taieb" sort="Ben Abdallah, Taieb" uniqKey="Ben Abdallah T" first="Taieb" last="Ben Abdallah">Taieb Ben Abdallah</name>
<name sortKey="Ben Slama, Riadh" sort="Ben Slama, Riadh" uniqKey="Ben Slama R" first="Riadh" last="Ben Slama">Riadh Ben Slama</name>
<name sortKey="Chebil, Mohamed" sort="Chebil, Mohamed" uniqKey="Chebil M" first="Mohamed" last="Chebil">Mohamed Chebil</name>
<name sortKey="Gargah, Tahar" sort="Gargah, Tahar" uniqKey="Gargah T" first="Tahar" last="Gargah">Tahar Gargah</name>
<name sortKey="Hedri, Hafedh" sort="Hedri, Hafedh" uniqKey="Hedri H" first="Hafedh" last="Hedri">Hafedh Hedri</name>
<name sortKey="Ounissi, Mondher" sort="Ounissi, Mondher" uniqKey="Ounissi M" first="Mondher" last="Ounissi">Mondher Ounissi</name>
<name sortKey="Zammouri, Asma" sort="Zammouri, Asma" uniqKey="Zammouri A" first="Asma" last="Zammouri">Asma Zammouri</name>
</noCountry>
<country name="Tunisie"><region name="Gouvernorat de Tunis"><name sortKey="Abderrahim, Ezzedine" sort="Abderrahim, Ezzedine" uniqKey="Abderrahim E" first="Ezzedine" last="Abderrahim">Ezzedine Abderrahim</name>
</region>
</country>
</tree>
</affiliations>
</record>

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Thirty Years of Experience at the First Tunisian Kidney Transplant Center.

Thirty Years of Experience at the First Tunisian Kidney Transplant Center.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki